Anus
From Pharmpedia
Antibiotics in their action are selective only on the bacterial cells and do not effect the host cells whereas viruses being integrated with the host cell are not (can not) be selective targets without affecting the host cell. Even if viruses are targeted selectively these will affect the host cell, not invariably, producing severe toxicity, indeed, because of the virus particle, a moocher’s obligate association with the host cell. Antibiotics, commonly, are targeted at (a) cell wall synthesis sites - cycloserine, bacitracin, and beta lactams glycopeptides, (b) folic acid metabolism sites - trimethoprim, sulfonamides, (c) cell membrane – polymixins, (d) DNA replication - quinolones, nitroimidazioles, (e) DNA dependant RNA polymerase – rifamycins, and (f) protein synthesis - amino glycosides macrlides, lincosamides, streptogramins, amphenicols, tetracyclines and rupirocin etc. Whereas in striking contrast, site of antiviral drugs (other than HIV inhibitors) include at the level of (A) adsorption – none, (B) fusion and penetration – none, (C) uncoating - amantadine, rimantadine, (D) transcriptions – interferon, (E) translations – fomovirsen, (F) RNA or DNA replication - nucleosides – acyclovir, adenine arabinoside, cidofovir ,acyclovir, foscarnet, ganciclovir, penciclovir, idoxuridine, ribavirin, sorivudine, triflurothymidine, (G) assembly – none, and (H) release and budding - zanamivir, oseltamvir. FDA
Retrieved from "http://www.pharmpedia.com/Anus"
This page has been accessed 209 times. This page was last modified 21:37, 10 December 2005. All content, except where otherwise noted, is licensed under a Creative Commons Attribution License.
