Direct compression method
From Pharmpedia
Direct compression method
The method consists of compressing tablets directly from powdered material without modifying the physical nature of the materials itself. This method of tablet making is of special interest for small group of crystalline chemicals having the entire physical characteristic necessary for the formulation of a good tablet. Substances like chlorides, chlorates, bromides, iodides, nitrates and permanganates, salts of potassium, ammonium chloride and methanamine etc are manufactured by direct compression as they have cohesive properties. Advantages of this method are simplicity of process, absence of granulating steps, avoidance of moisture and drying step, minimum material handling, and rapidity of the total process. The limitations of this method are that only a few crystalline drugs can be directly compressed otherwise this process has no other major limitation.
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