Dolasetron
From Pharmpedia
Dolasetron mesylate is an antinauseant and antiemetic agent. Chemically, dolasetron mesylate is (2,6,8,9ab)-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-lH-indole-3-carboxylate monomethanesulfonate, monohydrate. It is a highly specific and selective serotonin subtype 3 (5-HT3) receptor antagonist both in vitro and in vivo.
The empirical formula is C19H20N2O3 • CH3SO3H • H2O, with a molecular weight of 438.50. Approximately 74% of dolasetron mesylate monohydrate is dolasetron base.
Dolasetron mesylate monohydrate is a white to off-white powder that is freely soluble in water and propylene glycol, slightly soluble in ethanol, and slightly soluble in normal saline
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