Dry granulation method
From Pharmpedia
Dry granulation method
This process of granulation is also known as Slugging, double Compression or Recompression method. This process of tablet preparation is commonly used when the tablet ingredients are sensitive to moisture or are unable to withstand elevated temperature during drying. Under such conditions dry granulation is the method of choice provided the tablet ingredients have sufficient inherent binding or cohesive properties. The essential steps are weighing, mixing, slugging, dry screening, lubrication and compression. For the formation of a cohesive slug, spray dried or powdered binders such as acacia or microcrystalline cellulose may be added to the dry powder. Lubricants are added to reduce powder adhesion to the punches and to facilitate ejection of intact slugs from the dies. Initially large slugs are obtained by compressing powdered material containing excipients. The slugs are then forced through mesh screen breaking them into granules. The remaining lubricant is added to the granulation with gentle blending and the resulting material is compressed into tablet.
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