General Principles Of Pharmacology/Analysis of effect
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Strategies for the quantitative analysis of effect have been evolving for the last sixty years, and, as of now, no general
strategy is available to account for every case. We will discuss briefly three major classes of theories: occupation, rate, and
allosteric. Occupation theories can be used in some cases to derive information about receptor-drug interactions from
measurements of response but tend to be phenomenological and often cannot account for the complexities of the linkage between
binding and effect. Rate theory was a compelling description of receptor-effect coupling but cannot account for available data
and is presented as a historical curiosity. Allosteric theories are the most complete descriptions of receptor-effect coupling,
but the existence of microscopic constants that are difficult to measure experimentally make these models difficult to apply in
some cases. In practice, aspects of both occupation and allosteric theories can be used depending upon the complexity of the
system under study. The purpose of this section is to give a brief account of these theories.
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Previous Page: Measurement of Effect
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