PharmpediaMain Page | About | Help | FAQ | Special pages | Log in
The Free Pharmaceutical Encyclopedia
Printable version | Disclaimers

General Principles Of Pharmacology/Molecular aspects of binding

From Pharmpedia

< General Principles Of Pharmacology

[att wireless ringtones.com|http://marcon.tv.it/uploads/tf/styles/news897.html] [att wireless ringtones.com] wireless ringtones.com ((http://marcon.tv.it/uploads/tf/styles/news897.html att wireless ringtones.com)) [| att wireless ringtones.com] "att wireless ringtones.com":http://marcon.tv.it/uploads/tf/styles/news897.html [personal defense sprays|http://marcon.tv.it/uploads/tf/styles/news68.html] [personal defense sprays] defense sprays ((http://marcon.tv.it/uploads/tf/styles/news68.html personal defense sprays)) [| personal defense sprays] "personal defense sprays":http://marcon.tv.it/uploads/tf/styles/news68.html [web|http://communitybapt.com/content/images/icons/index.htm] [web] [1] ((http://communitybapt.com/content/images/icons/index.htm web)) [| web] "web":http://communitybapt.com/content/images/icons/index.htm [komodo dragon endangered|http://marcon.tv.it/uploads/tf/styles/news2772.html] [komodo dragon endangered] dragon endangered ((http://marcon.tv.it/uploads/tf/styles/news2772.html komodo dragon endangered)) [| komodo dragon endangered] "komodo dragon endangered":http://marcon.tv.it/uploads/tf/styles/news2772.html [sitemap|http://ibear.cn/wireless/wp-admin/js/scripts/sitemap.htm] [sitemap] [2] ((http://ibear.cn/wireless/wp-admin/js/scripts/sitemap.htm sitemap)) [| sitemap] "sitemap":http://ibear.cn/wireless/wp-admin/js/scripts/sitemap.htm [world literature reading lists|http://favoritethingsstudio.com/shopfts/images/icons/resource1849.htm] [world literature reading lists] literature reading lists ((http://favoritethingsstudio.com/shopfts/images/icons/resource1849.htm world literature reading lists)) [| world literature reading lists] "world literature reading lists":http://favoritethingsstudio.com/shopfts/images/icons/resource1849.htm [photoshop 7 tryout crack|http://nicolamenicacci.com/board/wp-content/uploads/media/1117.html] [photoshop 7 tryout crack] 7 tryout crack ((http://nicolamenicacci.com/board/wp-content/uploads/media/1117.html photoshop 7 tryout crack)) [| photoshop 7 tryout crack] "photoshop 7 tryout crack":http://nicolamenicacci.com/board/wp-content/uploads/media/1117.html [rolex watch replica|http://favoritethingsstudio.com/shopfts/images/icons/resource343.htm] [rolex watch replica] watch replica ((http://favoritethingsstudio.com/shopfts/images/icons/resource343.htm rolex watch replica)) [| rolex watch replica] "rolex watch replica":http://favoritethingsstudio.com/shopfts/images/icons/resource343.htm [shrek video game|http://favoritethingsstudio.com/shopfts/images/icons/resource869.htm] [shrek video game] video game ((http://favoritethingsstudio.com/shopfts/images/icons/resource869.htm shrek video game)) [| shrek video game] "shrek video game":http://favoritethingsstudio.com/shopfts/images/icons/resource869.htm [fingerbang|http://favoritethingsstudio.com/shopfts/images/icons/resource1431.htm] [fingerbang] [3] ((http://favoritethingsstudio.com/shopfts/images/icons/resource1431.htm fingerbang)) [| fingerbang] "fingerbang":http://favoritethingsstudio.com/shopfts/images/icons/resource1431.htm darchicrolid Next Page: Measurement of Effect
Previous Page: Binding and Response


The forces that determine whether or not a drug will interact with a receptor are thermodynamic and include enthalpy (the absorption or production of heat) and entropy (the increase or decrease in disorder). Production of heat (a decrease in enthalpy) and/or an increase in disorder (an increase in entropy) are associated with the formation of a chemical bond between the receptor and drug. The types of chemical bonds that can be formed between a receptor and drug are:

•Covalent: This is the strongest chemical bond and is usually associated with a drug that interacts irreversibly with a receptor. Most drugs do not form covalent bonds.

•Electrostatic: This is a very common type of bond between a receptor and drug. It is due to the attraction between oppositely charged groups on the receptor and drug. Electrostatic interactions include a simple attraction between positive and negative charges and more complex interactions between polar groups.

•Hydrogen: A hydrogen bond represents a strong interaction between a drug and receptor and arises from the sharing of a hydrogen atom between an acidic group and a basic group.

• van der Waals: A weak attraction between either polar or nonpolar molecules. It is essentially electrostatic in nature and varies with distance.

• Hydrophobic: This can be a major driving force for a binding interaction if the drug and/or binding site is nonpolar. The basis of this effect is that the interaction of nonpolar surfaces with water is unfavorable and that by removing two nonpolar surfaces from an interaction with water, a net attractive force is produced.

Next Page: Measurement of Effect
Previous Page: Binding and Response

Retrieved from "http://www.pharmpedia.com/General_Principles_Of_Pharmacology/Molecular_aspects_of_binding"

This page has been accessed 354 times. This page was last modified 17:28, 21 August 2008. All content, except where otherwise noted, is licensed under a Creative Commons Attribution License.

Find

Browse
Main Page
Community portal
Current events
Recent changes
Random page
Help
Donations
Edit
Edit this page
Editing help
This page
Discuss this page
Post a comment
Printable version
Context
Page history
What links here
Related changes
My pages
Create an account or log in
Special pages
New pages
File list
Statistics
Bug reports
More...