General Principles Of Pharmacology/Renal extraction ratio
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Excretion
Previous Page: Multiple Dose Kinetics
The fraction of a drug that is excreted when it passes through the kidneys is called the extraction ratio (ER) of the drug. By definition, a drug that is not excreted at all has an ER of 0 and a drug that is completely removed after a single passage has an ER of 1. The table below shows the extraction ratios for a number of drugs that are excreted in the urine (> 30% by this route): Extraction ratio:
Table 6: Renal Extraction Ratio of drugs
|
Low (< 0.2) |
Intermediate |
High |
|
Acetazolamide |
Procainamide |
(many) Glucuronides |
|
Chlorporpamide |
Quaternary ammonia compounds |
(many) Penicillins |
|
Diazoxide |
(many) Sulfates |
|
|
Digoxin |
(many) Glycine conjugates |
|
|
Furosemide |
||
|
Gentamicin |
||
|
Kanamycin |
||
|
Phenobarbital |
||
|
Sulfasoxazole |
||
|
Tetracycline |
Next Page: Drug Excretion:Mechanisms of Renal
Excretion
Previous Page: Multiple Dose Kinetics
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