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General Principles Of Pharmacology/Renal extraction ratio

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Previous Page: Multiple Dose Kinetics

The fraction of a drug that is excreted when it passes through the kidneys is called the extraction ratio (ER) of the drug. By definition, a drug that is not excreted at all has an ER of 0 and a drug that is completely removed after a single passage has an ER of 1. The table below shows the extraction ratios for a number of drugs that are excreted in the urine (> 30% by this route): Extraction ratio:

Table 6: Renal Extraction Ratio of drugs

Low (< 0.2)

Intermediate

High

Acetazolamide

Procainamide

(many) Glucuronides

Chlorporpamide

Quaternary ammonia compounds

(many) Penicillins

Diazoxide

 

(many) Sulfates

Digoxin

 

(many) Glycine conjugates

Furosemide

   

Gentamicin

   

Kanamycin

   

Phenobarbital

   

Sulfasoxazole

   

Tetracycline

   

Next Page: Drug Excretion:Mechanisms of Renal Excretion
Previous Page: Multiple Dose Kinetics

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