General Principles Of Pharmacology:Drug transformation and clinical considerations
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definitions and explanatory notes their glomerular filtration
The dose and the frequency of administration required achieving effective therapeutic blood and tissue levels vary in different patients because of individual differences in drug distribution and rates of drug metabolism and elimination. Genetic factors and nongenetic variables such as age, sex, liver size, liver function, circadian rhythm, body temperature, and nutritional and environmental factors such as concomitant exposure to inducers or inhibitors of drug metabolism determine these differences. The discussion that follows will summarize the most important variables relating to drug metabolism that are of clinical relevance.
Next Page: Individual Differences
Previous Page: Drug metabolism: some
definitions and explanatory notes their glomerular filtration
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