Oral tablets for ingestion:Delayed action tablet
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Enteric coated tablet is such an
example of delayed action tablet. This formulation is preferred when,
i)The API irritates gastric mucosa e.g., aspirin or strong electrolytes
ii)Drugs that produce nausea and vomiting.
iii)API is sensitive to low pH e.g., erythromycin
iv)When it’s necessary to release the drug undiluted. e.g., intestinal antibacterial, antiseptic agents, intestinal vermifuge, etc.
The commonly used coating agents are: Cellulose acetate phthalate, Hydroxy methyl propyl phthalate, polyvinyl acetate phthalate, Eudragit®, etc. This dosage form is intended to hydrate and begin to dissolve in duodenum (pH 4 to 6) or in small intestine where pH increases to 7 to 8. The presence of esterases or bile salts like surface active agents plays a role in drug release.
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