Oral tablets for ingestion:Standard compressed tablets
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These are the standard uncoated tablets made by either direct compression or wet granulation or dry granulation or double compaction.
FIGURE.1. STANDARD COMPRESSED TABLET
They may be used for local action in gastro-intestinal tract or systemic action. When the tablet exert local action, they are formulated as more water insoluble by means of selecting slow dissolving excipients and thus provides local action for long time period. e.g., antacids and adsorbents. The drugs that produce systemic action have some aqueous solubility and designed to disintegrate and dissolve quickly so that the drug can be quickly absorbed and produce systemic action. Generally, an API exhibits bioavailability depending upon Biopharmaceutical Class, which is based on water solubility and gastro-intestinal membrane permeability criteria. But, it can be altered by appropriate selection of excipients and processing technology.
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