Solid solution
From Pharmpedia
Solid solutions are homogeneous one phase system which exhibit a mixed crystal.
The particle size of the drug in the solid solution is reduced to its molecular size. Thus a solid solution can achieve a faster dissolution rate than the corresponding eutectic mixture.
The solid phases constiting the eutactic each contain one componant and the system may be regarrded as an intimate crystalline mixture of one component in the other.
Where as in solid solution each solid phase contains both componant. i.e. a solid solue is dissolved in a solid solventto give a mixed crystal.
- In those system where the solubility of one componant in the other in the solid state is significant solid solution is saild to exist.
- For practical purpose solubility greater that 5% of one componant in other considerd solid solution.
- Solid solutions can be classified by two methods.
- According to the extent of miscibility of the two components, they may be classified as continuous or discontinuous.
- According to the criterion of molecular size of the components, the solid solutions are classified as substitutional or interstitial.
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