Tablets used in the oral cavity:Sublingual tablet
From Pharmpedia
Next Page: Dental cones
Previous Page: Lozenges and troches
They are to be placed under the tongue and produce immediate systemic effect by enabling the drug absorbed directly through
mucosal lining of the mouth beneath the tongue.
FIGURE.11. SUBLINGUAL TABLETS
The drug absorbed from stomach goes to mesenteric circulation which connects to stomach via portal vein. Thus, absorption through oral cavity avoids first-pass metabolism. The tablets are usually small and flat, compressed lightly to keep them soft. The tablet must dissolve quickly allowing the API to be absorbed quickly. It’s designed to dissolve in small quantity of saliva. After the tablet is placed in the mouth below the tongue, the patient should avoid eating, drinking, smoking and possibly talking in order to keep the tablet in place. Swallowing of saliva should also be avoided since the saliva may contain dissolved drug. Bland excipients are used to avoid salivary stimulation. Due to inconvenience in administration, this dosage form is prepared only for those API(s) for which the only satisfactory nonparenteral method is this route. For example, Glyceryl trinitrate (vasodilator) and Isoprinosine sulphate (bronchodilator).
Next Page: Dental cones
Previous Page: Lozenges and troches
Retrieved from "http://www.pharmpedia.com/Tablets_used_in_the_oral_cavity:Sublingual_tablet"
This page has been accessed 800 times. This page was last modified 21:43, 8 August 2005. All content, except where otherwise noted, is licensed under a Creative Commons Attribution License.
